Csf2ra
WebDiseases associated with CSF2RA include surfactant metabolism dysfunction, pulmonary 4, and csf2ra-related pulmonary surfactant metabolism dysfunction. Description. CSF2RA … WebThe protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a c ytokine which controls the production, differentiation, and …
Csf2ra
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WebThe gene view histogram is a graphical view of mutations across CSF2RA. These mutations are displayed at the amino acid level across the full length of the gene by default. Restrict the view to a region of the gene by dragging across the histogram to highlight the region of interest, or by using the sliders in the filters panel to the left. WebJan 5, 2024 · Orthologous to human CSF2RA (colony stimulating factor 2 receptor subunit alpha). [provided by Alliance of Genome Resources, Apr 2024] Other designations. granulocyte-macrophage colony-stimulating factor receptor subunit alpha, GM-CSF-R-alpha, GM-CSFRalpha, GMCSFR-alpha, GMR-alpha, colony stimulating factor 2 receptor …
WebMay 2, 2024 · The congenital form of pulmonary alveolar proteinosis due to colony stimulating factor 2 receptor alpha gene mutations is a rare disease with only a few … WebNov 26, 2014 · Juvenile pulmonary alveolar proteinosis (PAP) due to CSF2RA mutations is a rare disorder with only a few cases described worldwide. We identified nine children …
WebSep 20, 2024 · To test this, colony stimulating factor 2 receptor alpha (Csf2ra) knockout (KO) mice that lack GM-CSF signaling and wild-type (WT) mice models of intratracheal … WebColony stimulating factor 2 receptor alpha, low-affinity (granulocyte-macrophage). CD116 molecule. Back to the top. Specifications Human CSF2RA isoform_1 (pUNO1 …
CSF2RA (Colony Stimulating Factor 2 Receptor Subunit Alpha) is a Protein Coding gene. Diseases associated with CSF2RA include Surfactant Metabolism Dysfunction, Pulmonary, 4 and Hereditary Pulmonary Alveolar Proteinosis.Among its related pathways are RAF/MAP kinase cascade and Interleukin-2 family signaling.Gene Ontology (GO) annotations related to this gene include signaling receptor activity ...
WebTo facilitate the translation of PMT therapy to human hPAP patients, a self-inactivating (SIN) lentiviral vector was generated expressing a codon-optimized human CSF2RA-cDNA driven from an EF1α short promoter (Lv.EFS.CSF2RA coop ), and a series of nonclinical efficacy and safety studies were performed in cultured macrophage cell lines and ... billy strings vinyl albumsWebThe colony stimulating factor 2 receptor alpha (Csf2ra) gene encodes GM-CSF receptor a (CD116) in mice. Defective GM-CSF receptor signaling results in abnormal development and functionality of billy strings white oak music hallWebDec 3, 2015 · CSF2RA expression also reduced the stemness of RUNX1-ETO bone marrow cells and inhibited their colony forming ability. To identify which region of the receptor was mediating these pro-apoptotic effects, we generated truncation mutants and determined that the 25 amino acids at the carboxyl-terminus of the intracellular domain of CSF2RA are … cynthia e nicholson guidryWebDec 1, 2024 · To facilitate the translation of PMT therapy to human hPAP patients, a self-inactivating (SIN) lentiviral vector was generated expressing a codon-optimized human CSF2RA-cDNA driven from an EF1α short promoter (Lv.EFS.CSF2RA coop), and a series of nonclinical efficacy and safety studies were performed in cultured macrophage cell … billy strings wikipediaWebOrder. Sequence variants and/or copy number variants (deletions/duplications) within the CSF2RA gene will be detected with >99% sensitivity. Variants classified as unknown … cynthia enloe patriarchyWebMar 9, 2024 · Hereditary pulmonary alveolar proteinosis (hPAP) is a rare disorder caused by recessive mutations in GM-CSF receptor subunit α/β genes (CSF2RA/CSF2RB, respectively) characterized by impaired GM-CSF-dependent surfactant clearance by alveolar macrophages (AMs) resulting in alveolar surfactant accumulation and … cynthia ensorWebLow affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of … cynthia enloe where are the women