Cisplatin lysosomes
WebJun 5, 2024 · Disrupting lysosomes with bafilomycin A1 increased the sensitivity of resistant cells to CDDP (Fig. 2K ). Fig. 2: Therapy-activated TFEB acts as a critical regulator to … WebLysosomes have been proposed to sequester drugs, including cisplatin, and may therefore contribute to drug resistance. However, the mechanism(s) that facilitate this remains unclear. Our work demonstrates that the CACC TMEM16A drives lysosomal … We would like to show you a description here but the site won’t allow us.
Cisplatin lysosomes
Did you know?
WebJun 2, 2016 · Cisplatin is a widely prescribed anticancer drug, which triggers cell death by covalent binding to a broad range of biological molecules. Among cisplatin targets, cellular RNAs remain the most poorly characterized molecules. WebNov 2, 2024 · Lysosomal exocytosis is a Ca 2+ -dependent process whereby lysosomes fuse with the plasma membrane and release their contents to the extracellular space [ 74]. Interestingly, lysosomal …
WebBafilomycin A1 increases the sensitivity of tongue squamous cell carcinoma cells to cisplatin by inhibiting the lysosomal uptake of platinum ions but not autophagy. Author links open overlay panel Hong-Ying Chu a b 1, Wei Wang a 1, Xue Chen a, ... Lysosome is a potential target for increasing the cytotoxicity of DDP. WebThe nanomaterial consists of peptide amphiphiles, which self-assemble into nanoparticles, colocalize with the lysosome, and change conformation to nanofibrils due to lysosomal pH shift, which leads to the disruption of the lysosome, cell death, and cisplatin sensitization.
WebOct 14, 2005 · Lysosomes are an essential part of the vesicular compartment and connect the outside medium with many classes of cellular targets in the cytosol, nucleus, … WebJan 1, 2016 · Ctr1 imports platinum-based drugs into the cell. The drug enters the nucleus, induces DNA crosslinking, resulting in DNA damage, cell cycle arrest and apoptosis (a). …
WebFeb 1, 2014 · Here we show that a synergistic interaction can be achieved between sunitinib and cisplatin through a mechanism involving both the apoptotic and the autophagic/lysosomal systems. Such drug cooperation results in enhanced growth inhibition and cell death in both MTC cell culture and tumor xenografts. Materials and Methods …
WebSep 25, 2024 · We investigated whether triggering lysosomal membrane permeabilization (LMP) or suppressing autophagy can restore cisplatin susceptibility in lung cancer with … poodle dye hairWebNov 7, 2024 · Although cisplatin is one of the most common antineoplastic drug, its successful utilisation in cancer treatment is limited by the drug resistance. Multiple … shapewear for fat girlsWebMay 10, 2024 · This HIF/Ferritin axis is responsible for etoposide- and cisplatin-induced iron reduction in lysosomes and stemness of SCLC cells. This work demonstrates that … poodle dogs for adoption near meWebApr 26, 2016 · Doxorubicin blocks autophagic flux in cardiomyocytes by impairing lysosome acidification and lysosomal function. Reducing autophagy initiation protects against doxorubicin cardiotoxicity. Doxorubicin blocks autophagic flux in cardiomyocytes by impairing lysosome acidification and lysosomal function. poodle ear hair removal toolWebSep 21, 2015 · Platinum-based cisplatin is a first-line therapeutic agent used in the treatment of multiple cancers, including ovarian cancer. Cisplatin acts by inducing DNA damage, triggering cell cycle arrest, and initiating apoptosis ( 4 ). However, many ovarian cancer patients develop acquired cisplatin resistance, resulting in failure of … poodle ear hairWebJun 2, 2016 · Cisplatin is a widely prescribed anticancer drug, which triggers cell death by covalent binding to a broad range of biological molecules. Among cisplatin targets, … poodle ear infection after groomingpoodle ear infection